Continuously updated synthesis method about

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., name: 2-Chloro-3-hydrazinylpyrazine

To a 0 0C solution of 2-(4-chlorophenyl)-2-methylpropanoic acid (99.3 mg, 0.50 mmol) in THF (2 mL) was added 4-methylmorpholine (60.5 muL, 0.55 mmol). After 10 minutes, isobutyl chloroformate (67.4 muL, 0.52 mmol) was added dropwise over 2 minutes. After 2.5 h, a solution of Compound IA (72.3mg, 0.50 mmol) in THF (3 mL) was added dropwise over 2 minutes. After 10 minutes the cooling bath was removed and the reaction mixture was warmed to room temperature. After 3 h at room temperature, water (5 mL) and ethyl acetate (10 mL) were added, and the resulting mixture was stirred for 10 minutes. At the conclusion of this period, the organic phase was separated, dried over Na2SO4, and then concentrated in vacuo to yield a residue. The residue was purified by flash chromatography (SiC^ , 0-100% ethyl acetate / hexanes) to provide compound IB, which was used directly in the preparation of compound 1C set forth below. LC/MS (m/z) = 325 (M+H)+.

According to the analysis of related databases, 63286-28-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2008/130951; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem