Electric Literature of 870787-06-7, These common heterocyclic compound, 870787-06-7, name is 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Diphenylphosphoryl azide (3.47g, 12.6mmol) was added to a stirred solution of 3- trifluoromethylpyrazine-2-carboxylic acid (1.92g, 9.70mmol) and triethylamine (1 .28g, 12.6mmol) in tert-butanol (9.6ml, l OOmmol) and toluene (19.2ml). The resulting mixture was heated at 90C for 4 hours and then allowed to cool. It was washed with 2M aqueous sodium bicarbonate, then dried through a phase-separation filter and concentrated under reduced pressure. The residue was purified by chromatography on silica gel using a gradient of ethyl acetate in isohexane as eluent to give tert-butyl N-(3- trifluoromethylpyrazin-2-yl)-carbamate (2.0g) as a colourless oil which slowly crystallised to give a white solid. (0268) 1H NMR (400MHz, CDCI3) delta 8.65 (d, 1 H), 8.40 (d, 1 H), 7.15 (br s, 1 H), 1 .55 (s, 9H).
Statistics shows that 3-(Trifluoromethyl)pyrazine-2-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 870787-06-7.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WAILES, Jeffrey, Steven; CARTER, Neil, Brian; CLOUGH, John, Martin; WILLIAMS, John; (57 pag.)WO2019/57723; (2019); A1;,
Pyrazine – Wikipedia,
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