These common heterocyclic compound, 870787-06-7, name is 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 870787-06-7
N- [2- (3,5- dichloro-pyridin-2-yl) -2- (tert- Butokishiimino) ethyl] -3-(trifluoromethyl) pyrazine-2-carboxamide 3- (tri N in dichloromethane 3ml solution of fluoromethyl) pyrazine-2-carboxylic acid 74mg, added N- dimethylformamide 10mg and oxalyl chloride 57mg, I was stirred at room temperature for 1 hour.After completion of the reaction, distilling off the solvent under reduced pressure, the residue was dissolved in dichloromethane 10ml, stirring under ice cooling, 2-amino-1- (3,5-dichloro-2-yl) ethanone -O- ( was added tert- butyl) oxime and triethylamine 89mg 39mg, it was continued for a further 1 hour stirring at room temperature.After completion of the reaction, extracted with added water 10ml reaction mixture chloroform (10mlx1), and the organic layer brine then dehydrated and dried in this order over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure.The residue was ethyl acetate – hexane (1: 9 to 3: 7 gradient) was purified by silica gel column chromatography eluting with a respective geometric isomers 22mg (isomer A) of the object and 111mg (isomers The B) it was obtained as a colorless resin-like substance
The synthetic route of 3-(Trifluoromethyl)pyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NISSAN CHEMICAL INDUSTRIES LIMITED; Iwasa, Motoyoshi; Tomizawa, Mitsutaka; Tsuji, Keisuke; Nakamura, Toshiyuki; Mita, Takeshi; Kuwahara, Hidehito; asahi, Miho; Imanaka, Hotaka; (342 pag.)JP2016/11286; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem