Electric Literature of 54608-52-5, A common heterocyclic compound, 54608-52-5, name is 2-Hydrazinopyrazine, molecular formula is C4H6N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
441 mg (2.0 mmol) of the compound from Example 12A and 220 mg (2.0 mmol) of the compound from Example 3A are initially charged in 10 ml of ethanol. 93 mg (0.4 mmol) of camphor-10-sulfonic acid are added, and the mixture is stirred under reflux for 5 h. The mixture is allowed to cool to RT, and the solid formed is filtered off and washed once with a little ethanol. 10 ml of a 4 N solution of hydrogen chloride in dioxane are then added, and the mixture is stirred at RT for 30 min. The mixture is then concentrated on a rotary evaporator, and the residue is dried under high vacuum.Yield: 260 mg (47% of theory)LC-MS (Method 1): Rt=1.93 min; MS (ESIpos): m/z=240 [M+H]+;1H-NMR (400 MHz, DMSO-d6): delta=9.70 (s, 1H), 9.43 (s, 1H), 9.08 (d, 1H), 9.01 (s, 1H), 8.70 (d, 1H), 8.61 (s, 2H), 8.08 (dd, 1H).
The synthetic route of 54608-52-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Thede, Kai; Flamme, Ingo; Oehme, Felix; Ergueden, Jens-Kerim; Stoll, Friederike; Schuhmacher, Joachim; Wild, Hanno; Kolkhof, Peter; Beck, Hartmut; Akbaba, Metin; Jeske, Mario; US2012/264704; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem