Application of 41270-62-6,Some common heterocyclic compound, 41270-62-6, name is 2-Chloro-6-phenylpyrazine, molecular formula is C10H7ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of ( (S)-tert-butyl 4-((2-acetamidoethyl) (4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl) butyl)amino)-2-aminobutanoate (150 mg, 335 mol) and 2-chloro-6-phenylpyrazine (53 mg, 279 mol) in t-AmOH (3 mL) was added 2.0M t-BuONa (279 muL, 558 mol) then t-BuXphos Pd G3 (22 mg, 28 mol) and the resulting mixture was heated to 100 C. for 15 h, cooled to rt, and then concentrated in vacuo to give the title compound that was used without further purification. LCMS (ESI+): m/z=602.5 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-6-phenylpyrazine, its application will become more common.
Reference:
Patent; Pliant Therapeutics, Inc.; CHA, Jacob; DONG, Chengguo; HOM, Timothy; JIANG, Lan; LEFTHERIS, Katerina; LI, Hui; MORGANS, JR., David J.; MUNOZ, Manuel; REILLY, Maureen; ZHENG, Yajun; (232 pag.)US2019/276449; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem