In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 173253-42-4 as follows. Computed Properties of C4H3BrClN3
Example 6 2-Amino-5,7-dihydrofuro[3,4-b]pyrazine A mixture of 2-amino-5-bromo-6-chloro-pyrazine (21 mg, 0.10 mmol), tributyl{[tributylstannyl)methoxy]methyl}stannane according to Production Example 1-2 (62 mg, 0.10 mmol), tris(dibenzylideneacetone)dipalladium (9.2 mg, 0.010 mmol), X-Phos (19 mg, 0.040 mmol), and 1,4-dioxane (1.0 mL) was stirred while being heated to reflux for 20 hours. The resulting mixture was cooled to room temperature and then filtered through Celite and concentrated under reduced pressure. The residue was separated and purified by preparative thin-layer chromatography (ethyl acetate_heptane=5:1) to obtain the title compound (3.6 mg, 26% yield). 1H-NMR Spectrum (400 MHz, CDCl3) delta (ppm): 4.55 (br s, 2H), 4.87-5.13 (m, 4H), 7.83 (s, 1H).
According to the analysis of related databases, 173253-42-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Eisai R&D Management Co., Lt.d; Tanaka, Keigo; Fukuyama, Takashi; Murai, Norio; Itano, Wataru; Hirota, Shinsuke; Iida, Daisuke; Azuma, Hiroshi; (32 pag.)US2016/168176; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem