Share a compound : 16298-03-6

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16298-03-6.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16298-03-6, name is Methyl 2-aminopyrazine-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C6H7N3O2

3-Aminopyrazine-2-carboxylic acid methyl ester (2.5 g, 16.3 mmol), di-tert.-butyldicarbonate (7.5 g, 34.4 mmol) and 4-(N,N-dimethylamino)pyridine (0.1 g, 0.8 mmol) were dissolved in 100 mL dichloromethane and refluxed for 4 hrs. The reaction mixture was cooled and extracted with sat. NaHCO3- solution and ethyl acetate. The organic extract was dried with sodium sulfate, filtered and evaporated. The crude product was purified by flash chromatography on silica gel (heptane/ethyl acetate 90:10->1:1 gradient). The desired compound was obtained as a white solid (4.7 g, 81percent), MS: m/e=354.0 (M+H+).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16298-03-6.

Reference:
Patent; Jaeschke, Georg; Kolczewski, Sabine; Porter, Richard Hugh Philip; Vieira, Eric; US2006/199828; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem