Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
4.7 (R)-tert-Butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate 9 (R)-3-(tert-Butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid 7 (200 mg, 0.59 mmol) and 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazinehydrochloride 8 (115 mg, 0.59 mmol) in anhydrous DCM (3 mL) were cooled to 0 C. To that solution was added HOBT (96 mg, 0.7 mmol), followed by EDC·HCl (134 mg, 0.7 mmol) and DIEPA (152 mg, 1.18 mmol). After being stirred for 24 h, DCM was evaporated, and the viscous residue was partitioned between ethyl acetate and saturated aqueous NaHCO3 solution. The aqueous layer was extracted with ethyl acetate. The combined organic phase was washed with brine, dried over Na2SO4, and concentrated. The crude product was purified by column chromatography eluting with 80% ethyl acetate in hexane to afford 9 as a white powder (280 mg, 92% yield). Mp: 189-192 C; {lit. 8a mp: 188-191 C}; [alpha]D25.1 = +20.8 (c 0.11, CHCl3); {lit. 8a [alpha]D20 = +22.2 (c 1.0, CHCl3)}; 1H NMR (500 MHz, CDCl3) delta 1.35 (s, 9H), 2.93-2.67 (m, 4H), 4.17-3.97 (m, 5H), 4.92 (s, 1H), 5.07-5.00 (m, 1H), 5.28 (s, 1H), 6.88 (s, 1H), 7.08-7.06 (d, J = 6.36 Hz, 1H). 13C NMR (125 MHz, CDCl3) delta 28.2, 32.9, 36.7, 38.0, 39.2, 41.8, 42.6, 43.1, 43.6, 48.2, 48.4, 79.7, 105.2, 105.3, 105.4, 105.5, 117.1, 119.0, 119.1, 121.4, 143.7, 144.0, 145.6, 147.7, 147.9, 149.4, 149.9, 150.2, 155.2, 157.1, 169.5, 169.9; MS (ESI) m/z: 507.9 (M+H)+. HRMS (ESI) (M+H)+: calcd for C21H23F6N5O3: 508.1778; found: 508.1778.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 762240-92-6.
Reference:
Article; Subbaiah; Haq, Wahajul; Tetrahedron Asymmetry; vol. 25; 13-14; (2014); p. 1026 – 1030;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem