In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6863-73-6, name is 3-Chloropyrazin-2-amine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Formula: C4H4ClN3
Sodium hydride (188.6 mg, 4.72 mmol) in N, N- dimethylformamide (3 mL) was slowly added dropwise at room temperature and benzyl alcohol was dissolved in it and it was stirred at room temperature for 1 hour. It was added dropwise slowly to a mixture of 2-amino-3-chloro-pyrazine and heating at 100 C refluxed for 15 hours. After cooling the reaction to room temperature and the solvent was evaporated under reduced pressure and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, filter and concentrate under reduced pressure . By separation and purification of the residue by column chromatography (ethyl acetate / n-hexane = 1/4) to obtain the objective compound 300 mg at a yield of 53.76%.
The synthetic route of 6863-73-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Korea Institute of Science and Technology; Choo, Hyeon Ah; Bae, Ae Nim; Kim, Ji Yoon; Park, Pyong Gon; Lee, Ji Yeon; Noh, Eun Joo; Park, Jong Eun; Ra, Hyeon Hwa; (104 pag.)KR101481952; (2015); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem