Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 59489-71-3, name is 2-Amino-5-bromopyrazine, This compound has unique chemical properties. The synthetic route is as follows., name: 2-Amino-5-bromopyrazine
Example 17-7 Synthesis of 6-bromoimidazo[1,2-a]pyrazine A mixture of bromoacetaldehyde diethylacetal (19.7 g, 0.1 M) and 48% hydrobromic acid (4 ml) was heated to 140 C under nitrogen for 1.5 hours. The resulting mixture was poured onto a stirred suspension of sodium bicarbonate (40 g) in propan-2-ol (200 ml) and the resulting suspension was stirred for 10 minutes and then filtered. 5-Bromo-pyrazine-2-ylamine 12* (8.65 g, 0.05 M) was added to the filtrate and the resulting solution was heated at reflux for two hours. The solvent was evaporated in vacuo to give dark brown viscous material. The residue was treated with saturated sodium bicarbonate (150 ml) and extracted twice with dichloromethane (500 ml). The combined extracts were dried and evaporated in vacuo to give a brown oil, which was purified by flash chromatography with ethyl acetate as eluant to give 7.0 g of the desired product 16* as a light brown solid (Yield 71%). 1H-NMR (400 MHz, CDCl3): delta = 7.71 (s, 1 H, Ar), 7.85 (s, 1 H, ArH), 8.30 (s, 1 H, ArH), 8.92 (s, 1 H, ArH).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 59489-71-3.
Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; Ullrich, Axel; Falcenberg, Mathias; EP2818471; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem