Some common heterocyclic compound, 1245644-42-1, name is 6-Bromo-3-iodoimidazo[1,2-a]pyrazine, molecular formula is C6H3BrIN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 6-Bromo-3-iodoimidazo[1,2-a]pyrazine
General procedure: 6-Bromo-3-thiophen-2-yl-imidazo[1,2- a]pyrazine 18*c Note: An additional 1 mol% of Palladium Acetate and triphenylphosphine was added after 12 hours to increase the yield of the reaction. 1H-NMR (400 MHz, CDCl3): delta = 8.94 (s, 1 H), 8.49 (s, 1 H), 7.95 (s, 1 H), 7.55 (d, J =5.2Hz, 1 H), 7.38 (d, J =3.2Hz, 1 H), 7.27 (s, 1H). Yield: 42.3%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1245644-42-1, its application will become more common.
Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; Ullrich, Axel; Falcenberg, Mathias; EP2818471; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem