Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1458-01-1, name is Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 1458-01-1
Preparation 1Methyl 3,5-diamino-6-r2-(trifluoromethoxy)phenyllpyrazine-2-carboxylateMETHOD AMethyl 3,5-diamino-6-chloropyrazine~2-carboxylate (1.62 g, 8.0 mmol) was combined with 2-(trifluoromethyl)phenylboronic acid (3.29 g: 16.0 mmol), palladium tetrakistriphenylphosphine (0.924 g, 0.80 mmol) and cesium carbonate (2.61 g, 8.0 mmol) and suspended in a mixture of 1 ,4-dioxane (30 ml) and water (15 ml). The reaction was sealed and heated to 750C for 4 hours before cooling to room temperature. Water (150 ml) was added and the 1 ,4-dioxane removed in vacuo. The precipitate formed was collected by filtration and dried. The brown solid was triturated with dichloromethane:methanol, then purified by silica gel column chromatography eluting with 95:5 dichloromethane:methanol to afford the title compound as a yellow solid (1.66 g, 63percent yield).1HNMR (d6-DMSO): 3.7 (s, 3H), 6.59 (br s, 2H), 7.10 (br s, 2H), 7.41-7.64 (m, 4H) LCMS Rt=8.64 min MS m/z 329 [MH]+
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1458-01-1.
Reference:
Patent; PFIZER LIMITED; WO2008/135830; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem