Application of 2423-65-6, A common heterocyclic compound, 2423-65-6, name is Pyrazine 1-oxide, molecular formula is C4H4N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Synthesis of meso-substituted calixarenes 4a-f (general procedure). A 1.6 M solution of BunLi in hexane (1.44 mL, 2.3 mmol) was added to a vigorously stirred solution of TMEDA (0.43 mL, 2.9 mmol) in anhydrous THF (4 mL) cooled to -78 C. After 40 min of stirring, a solution of 25,26,27,28-tetramethoxycalix[4]arene (480.5 mg, 1.0 mmol) in anhydrous THF (5 mL) was added, the reaction mixture was warmed up to room temperatures and stirred for another 2 h. The solution of formed 2-lithium-25,26,27,28-tetramethoxycalix[4]arene (1) was cooled to -78 C, and a solution of the corresponding azine N-oxide 2a-f (2.0 mmol) in anhydrous THF (6 mL) was added. The reaction mixture was stirred at room temperature for 1 h, followed by the addition of AcCl (0.14 mL, 2.0 mmol). The mixture was concentrated at reduced pressure. The residue was subjected to column chromatography on SiO2, the eluate was concentrated dry in vacuo.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Varaksin; Chupakhin; Charushin; Khlamkin; Utepova; Russian Chemical Bulletin; vol. 64; 5; (2015); p. 1093 – 1096; Izv. Akad. Nauk, Ser. Khim.; 5; (2015); p. 1093 – 1096,4;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem