Adding a certain compound to certain chemical reactions, such as: 17231-51-5, name is 3-Amino-6-bromopyrazine-2-carbonitrile, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17231-51-5, category: Pyrazines
Step 2: synthesis of 3,6-dibromopyrazine-2-carbonitrile (15)To a solution of copper(ii) bromide (1.432 g, 6.41 mmol) and tert-butylnitrite (0.769 mL, 6.41 mmol) in acetonitrile (40 mL) was added 3-amino-6-bromopyrazine-2- carbonitrile 14 (1.16 g, 5.83 mmol) in portions (in 2h). The reaction was stirred for 2h at 50C. Quenched with 2N HC1 solution and the resulting precipitate was collected. Purification by chromatography (CH2CI2) gave pure 3,6-dibromopyrazine-2- carbonitrile 15 (820 mg, 53.5 %). 1H-NMR (400 MHz, CDC13) 8.66 (s, 1H). (m/z) = 261, 263 and 265 (M+H)+.
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Reference:
Patent; N.V. ORGANON; FOLMER, Brigitte, Johanna, Bernita; MAN, de, Adrianus, Petrus, Antonius; GERNETTE, Elisabeth, Sophia; CORTE REAL GONCALVES AZEVEDO, Rita; IBRAHIM, Hemen; WO2011/147764; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem