98-97-5, name is Pyrazine-2-carboxylic acid, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C5H4N2O2
General procedure: The N-hydroxysuccinimide esters of pyrazinecarboxylic acidand (S)-(+)-ibuprofen were prepared by dissolving the starting acid(0.200 g, 1.0 equiv) in dry tetrahydrofuran and setting to stir at 0C. N-Hydroxysuccinimide (1.0 equiv) was added followed by N,N0-dicyclohexylcarbodiimide (1.0 equiv). The mixture was warmedto room temperature and stirred for 24 h. The N,N?-dicyclohexylureawas removed by filtration and the filtrate was concentratedto afford a solid that was purified by column chromatography..
The synthetic route of 98-97-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bakas, Nicole A.; Schultz, Chad R.; Yco, Lisette P.; Roberts, Christopher C.; Chang, Chia-en A.; Bachmann, Andre S.; Pirrung, Michael C.; Bioorganic and Medicinal Chemistry; vol. 26; 2; (2018); p. 401 – 412;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem