Electric Literature of 126069-70-3,Some common heterocyclic compound, 126069-70-3, name is 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine, molecular formula is C7H8F3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 1.0 g (5.23 mmol) 2- (TRIFLUOROMETHYL)-5, 6,7, 8- tetrahydroimidazo [1, 2-a] pyrazine (Step A) in 50 mL of dichloromethane at 0 C was added N, N- diisopropylethylamine (0.910 mL, 5.23 mmol) and di-tert-butyl dicarbonate (1.14 g, 5.24 mmol). After the reaction was stirred at 0 C for 5 min, the reaction was warmed to ambient temperature and continued to stir for 4 h. The reaction mixture was partitioned between ethyl acetate and 0. 5N hydrochloric acid. The aqueous phase was extracted with three potions of ethyl acetate. The combined organic layers were washed with brine, dried over magnesium sulfate, and concentrated. The residue was purified by flash chromatography using a BIOTAGE system (silica gel, 50% ethyl acetate in hexanes then 100% ethyl acetate) to give the title compound as a solid. LC/MS 236 (M+1-56).
The synthetic route of 126069-70-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK & CO., INC.; WO2004/58266; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem