Reference of 36070-75-4,Some common heterocyclic compound, 36070-75-4, name is 5-Chloropyrazine-2-carbonitrile, molecular formula is C5H2ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of 3-hydroxy-5-isopropoxy-N-(1-methyl-1H-pyrazol-3-yl)benzamide (492 mg), potassium carbonate (445 mg), and N-methylpyrrolidone (NMP) (4 mL) was added a solution of 5-chloropyrazine-2-carbonitrile in NMP (3 mL) under ice-cooling, followed by stirring at room temperature for 4 hours and at 50C for 20 minutes. Diethyl ether (20 mL) and water (20 mL) were added thereto to carry out liquid separation, the organic layer was washed with water (20 mL) and saturated brine (20 mL) in this order, and the aqueous layer was extracted again with diethyl ether (20 mL). The combined organic layer was dried over anhydrous magnesium sulfate and then filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane-ethyl acetate=1:1 to 1:2) to obtain 3-[(5-cyanopyrazin-2-yl)oxy]-5-isopropoxy-N-(1-methyl-1H-pyrazol-3-yl)benzamide (632 mg) as a light yellow oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Chloropyrazine-2-carbonitrile, its application will become more common.
Reference:
Patent; Astellas Pharma Inc.; EP2511265; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem