Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 36070-80-1
To a suspension of 5-chloropyrazine-2-carboxylic acid (1.00 g, 631 mmol) in dichloromethane (12 mL) and DMF (0.015 mL) at rt was added oxalyl chloride (0.804 mL, 7.25 mmol) drop wise over 10 min. The mixture was stirred at rt for 2 h before it was concentrated under vacuum to dryness. Tire residue was dissolved in dichloromethan (15 mL). Dimethylamine in THF (3.94 mL, 7.88 mmol) was added at rt over 10 min, followed by triethylamine (1.934 mL, 13.88 mmol). The mixture was stirred at rt for 2 h. The mixture was diluted with ethyl acetate (50 mL) and filtered through Cehte. The filtrate was concentrated under vacuum to dryness, and the residue was applied to flash chromatograph (80 g silica gel, solid loading, 65-100% ethyl acetate) to provide the desired product, 5-chloro-N,N-dimethylpyrazine-2-carboxamide (1.07 g, 5.76 mmol, 91 % yield), as a white solid. LCMS m z 186.1 (M+H)+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; XIAO, Zili; YANG, Michael G.; LIU, Chunjian C.; SHERWOOD, Trevor C.; GILMORE, John L.; WEINSTEIN, David S.; (152 pag.)WO2019/183186; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem