Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16298-03-6, name is Methyl 2-aminopyrazine-3-carboxylate, A new synthetic method of this compound is introduced below., Safety of Methyl 2-aminopyrazine-3-carboxylate
In 20 ml of concentrated hydrochloric acid, 3.06 g (20 mmol, 1 eq.) of 3-amino-2-pyrazine methyl carboxylate is introduced at 0 C. A solution of 1.52 g (22 mmol, 1.1 eq.) of NaNO2 in 15 ml of water is then introduced drop by drop, while limiting the temperature to <5 C., until the gaseous emission stops. The solution obtained is filtered and added slowly to a sodium acetate solution (20 g) in 40 ml of water at 0 C. Stirring is maintained for 15 min, and then acidified with concentrated HCl. Extraction (4 times 30 ml of ethyl acetate) gives 1.35 g of chlorinated compound after drying and evaporation. NMR (1H, CDCl3): 4.05 (s; 3H; OCH3), 8.54 (d, J=2.4 Hz; 1H; arom. H), 8.60 (d, J=2.4 Hz; 1H; arom. H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Imbert, Thierry; Monse, Barbara; Koek, Wouter; US2005/80085; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem