In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54608-52-5, name is 2-Hydrazinopyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Hydrazinopyrazine
2-((3 -(3 ,5-bis(trifluoromethyl)phenyl)- 1-1 ,2,4-triazol- 1 -yl)methyl)acrylic acid (0.2 g, 0.54 mmol) was dissolved in THE (10 mL) and cooled to 0 C. 2- hydrazinopyrazine (0.072 g, 0.65 mmol) followed by T3P (0.7 mL, 1.09 mmol) andDIPEA (0.4 mL, 2.19 mmol) was added dropwise at 0 C and stuffed for 1 h. The reaction mixture was concentrated under reduced pressure to afford 0.3 g of crude product, which was purified by chromatography (0-5% dichloromethane-methanol) to afford 10 mg of2-((3-(3, 5-bis(trifluoromethyl)phenyl)- 1H- 1,2, 4-triazol- 1 -yl)methyl)-N-(pyrazin-2-yl)acrylohydrazide (Yield: 4%). ?H NMR (400 MHz, DMSO-d6, ppm) = 10.34 (s,1H); 8.92 (s, 1H); 8.73 (s, 1H); 8.51 (s, 2H); 8.29 (s, 1H); 7.99 (s, 1H); 7.87-7.93 (m, 2H); 6.14 (s, 1H); 5.74 (s, 1H); 5.19 (s, 2H): LCMS for C18H14F6N70 [M+Hj:calculated 458.33; found 458.19.
The synthetic route of 54608-52-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KARYOPHARM THERAPEUTICS INC.; KATOLIEKE UNIVERSITEIT LEUVEN; SANDANAYAKA, Vincent, P.; SHECHTER, Sharon; DAELEMANS, Dirk; LEEN, Volker; DEHAEN, Wim, Alfons; SHACHAM, Sharon; WO2014/152263; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem