Adding a certain compound to certain chemical reactions, such as: 1053656-22-6, name is 7-tert-Butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1053656-22-6, Recommanded Product: 7-tert-Butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate
To a chloroform solution (250 ML) of ethyl 7- (TERT-BUTOXYCARBONYL)-5, 6,7, 8- tetrahydroimidazo [1, 2-a] pyrazine-2-carboxylate from Example 10, Step A (18.4 g, 94 mmol), bromine (45 g, 281 mmol) was added, and the mixture was stirred at room temperature for an hour. An aqueous solution of sodium bisulfite was then added and the product was extracted with two 100-ML portions of dichloromethane. The combined organic extracts were washed sequentially with sodium bicarbonate and brine, then dried over sodium sulfate and concentrated in vacuo. The crude material was purified by flash chromatography (silica gel, gradient elution, 50% ethyl acetate/hexane to 100% ethyl acetate) to give the title compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-tert-Butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate, and friends who are interested can also refer to it.
Reference:
Patent; MERCK & CO., INC.; WO2004/58266; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem