Reference of 5049-61-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5049-61-6 name is Pyrazin-2-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 1 ) Formation of 5-Bromopyrazin-2-amine N-bromosuccinimide (22.4 g, 0.126 mol) was added portionwise to a stirred solution of 2-Aminopyrazine (15 g, 157 mmol) in CCI4 (500 ml.) at O0C. The reaction mixture was stirred at RT under nitrogen atmosphere. After 3 hours, the reaction mixture was filtered and the filtrate was concentrated under vacuum. The crude material was purified by flash chromatography on silica (PE:EtOAc) to give the title compound as a yellow solid. LC/MS (Atlantis), M+(ESI): 173.8.1H-NMR (DMSO-d6, 400 MHz) delta 8.01 (1 H, s), 7.66-7.67 (1 H, s), 6.63 (2H, brs).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Pyrazin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SERONO S.A.; SWINNEN, Dominique; JORAND-LEBRUN, Catherine; GRIPPI-VALLOTTON, Tania; GERBER, Patrick; GONZALEZ, Jerome; SHAW, Jeffrey; JEYAPRAKASHNARAYANAN, Seenisamy; WO2010/100144; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem