Adding a certain compound to certain chemical reactions, such as: 1208082-91-0, name is 6,8-Dibromo-2-methylimidazo[1,2-a]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1208082-91-0, Quality Control of 6,8-Dibromo-2-methylimidazo[1,2-a]pyrazine
A mixture of Intermediate 1-05 (1.75 g, 6.015 mmol), morpholine (0.526 mE, 6.015 mmol) and DCM (20 mE) was stirred at rt for 16 h. Additional morpholine (0.52 6 mE,6.015 mmol) was added and the mixture was stirred at rt for18 h more. Na2CO3 sat. aq. was added. The organic phase was separated, dried (Na2SO4), filtered and evaporated till dryness to obtain 1.8 g of intermediate 1-10 (Y: quantitative). The resulting product was used in the next step without further purification.
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Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); Serrano Marugan, Manuel; Pastor Fernandez, Joaquin; Martinez Gonzalez, Sonia; Ortega Molina, Ana; Bischoff, James R.; Oyarzabal Santamarina, Julen; (220 pag.)US9993554; (2018); B2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem