Synthetic Route of 912773-24-1, The chemical industry reduces the impact on the environment during synthesis 912773-24-1, name is 6-Bromoimidazo[1,2-a]pyrazine, I believe this compound will play a more active role in future production and life.
To a solution of 6-bromoimidazo [1,2-a]pyrazine (1.43 g, 7.26 mmol, 1.0 equiv) in DMF (50 mL) was added NBS (1.39 g, 7.81 mmol, 1.1 equiv) at -5~0 C. The resulting solution was stirred at 0 C for 1 hr. The resulting mixture was diluted with ethyl acetate (300 mL) then washed with brine. The organic layer was dried and concentrated to obtain 1.8 g of the crude product as a white solid. (ES, m/z): [M + H+] 278; H-NMR (300 MHz, CDCI3): 5 8.92 (d, J= 1.2 Hz, 1H), 8.28 (s, 1H), 7.84 (d, J= 1.2 Hz, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Bromoimidazo[1,2-a]pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; IRM LLC; NOVARTIS AG; CHATTERJEE, Arnab Kumar; NAGLE, Advait Suresh; PARASELLI, Prasuna; LEONG, Seh Yong; ROLAND, Jason Thomas; MISHRA, Pranab Kumar; YEUNG, Bryan KS; ZOU, Bin; WO2014/78813; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem