Application of 873-40-5, The chemical industry reduces the impact on the environment during synthesis 873-40-5, name is 2,3,5-Trichloropyrazine, I believe this compound will play a more active role in future production and life.
2, 3, 5-trichloropyrazine (70.50 g, 384.36 mmol, 1 equiv) and ammonia solution (25% wt, 364.00 g, 400 mL, 2.68 mol, 6.14 equiv) were added to a l-L sealed reactor. The mixture was heated to 80 C and stirred for 24 h, and the reaction was completed. The reaction mixture was cooled to 30 C and filtered to give a brown filter cake. The brown filter cake was dissolved in acetone (50 mL), and filtered. To the filtrate was added petroleum ether (300 mL). The suspension was stirred for 4 h, and filtered to give the crude product. The crude product was slurried in combined solvents of petroleum ether and acetone (10/1, 200 mL) and filtered to give the product Y7d (51.00 g, 307.91 mmol, 80% yield) as a light yellow solid. 1H NMR (400 MHz, DMSO-d6) d = 7.63 (s, 1H). The advantage of this (also generalized) method is that no column chromatography is required to obtain Y7d.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,3,5-Trichloropyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; FEI, Zhongbo; ZHANG, Hao; JIA, Huanqing; WANG, Hui; WANG, Jianhua; LI, Wei; LIN, Xiaohui; MIN, Zhongcheng; (91 pag.)WO2020/65452; (2020); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem