Electric Literature of 33332-29-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 33332-29-5 as follows.
Step 2: Preparation of 2,5-dichloropyrazine; 5-Chloropyrazin-2-amine (5.0 g, 38.6 mmol) was dissolved in acetonitrile (77 ml) under a balloon of N2. The copper(I) chloride (5.7 g, 57.9 mmol) and copper(ET) chloride (7.8 g, 57.9 mmol) were added and the slurry cooled to -1O 0C with an ice:acetone bath. t-Butyl nitrite (9.15g, 89 mmol, 90percent) was added dropwise and the solution allowed to warm to RT. The solution was stirred for 30 minutes until rapid gas evolution ceased. The mixture was heated to 65 0C for 2.5 hours. The mixture was cooled to RT and filtered through a 1.5 inch pad of celilte packed into a 465 ml frit. The pad was washed with DCM (200 ml x 4), the wash fractions containing the desired material combined, filtered, and concentrated in vacuo.
According to the analysis of related databases, 33332-29-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK & CO., INC.; WO2008/85316; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem