33332-25-1, name is Methyl 5-chloropyrazine-2-carboxylate, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: Methyl 5-chloropyrazine-2-carboxylate
A mixture of 3-Cyclopentyl-7- (4-piperidinyl)-2, 3,4, 5-tetrahydro-1 H-3-benzazepine (product of E230, step 2) (0.5g, 1. 68mol), potassium carbonate (0.46g, 3. 35mmol) and methyl 5- chloro-2-pyrazinecarboxylate (0.58g, 3. 35mmol) in dimethylformamide (20ml) was heated at 90C for 3 hours. The crude mixture was purified on an SCX ion exchange cartridge eluting with methanol and then 2M ammonia in methanol. The basic fractions evaporated and the residue purified by column chromatography on silica eluting with 95-5 dichloromethane-2M ammonia in methanol to afford the title compound as a yellow solid (0.55 g, 75%) MS (AP+) m/e 435 [M+H] +.
The synthetic route of 33332-25-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2005/87746; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem