Adding a certain compound to certain chemical reactions, such as: 875781-43-4, name is 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 875781-43-4, Computed Properties of C6H4BrN3
2.1 1.66 g (2.37 mmol) of bis(triphenylphosphine)palladium dichloride and 16.8 g (80 mmol) of 1-methyl-1H-pyrazole-4-boronic acid pinacol ester are added successively to a solution, kept under nitrogen, of 9.4 g (47.0 mmol) of 2-bromo-5H-pyrrolo[2,3-b]pyrazine (prepared in two steps from 3,5-dibromopyrazin-2-amine in accordance with WO2006/15124 or WO2010/68483) in 400 ml of dioxane, and the mixture is stirred at room temperature for 5 minutes. 94 ml of a 2 M aqueous sodium carbonate solution are then added. The mixture is heated to 90 C. and kept at this temperature for 2 hours. The reaction mixture is cooled to room temperature and partitioned between water and ethyl acetate. The combined organic phases are dried over sodium sulfate and evaporated. The residue is boiled in tert-butyl methyl ether, cooled and filtered off with suction. The residue is dried in vacuo: 2-(1-methyl-11H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine as orange crystals; HPLC/MS: 1.30 min, [M+H] 200.
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Reference:
Patent; MERCK PATENT GMBH; Dorsch, Dieter; Wucherer-Plietker, Margarita; Mueller, Thomas J.J.; Merkul, Eugen; US2013/217951; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem