Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 767340-03-4, name is (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine, A new synthetic method of this compound is introduced below., Recommanded Product: (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine
Example-26: Preparation of racemic sitagliptin compound of formula-18:; Sodium borohydride (2.34 grams) was added to a mixture of compound of formula-17 (25 grams) in toluene at 5-100C. Acetic acid (75 ml) was added to it and stirred for 3 hours. The reaction mixture was quenched with water and then layers were separated. The aqueous layer was basified with aqueous sodium hydroxide and then the reaction mixture extracted into methylene chloride. The extracted methylene chloride dried over sodium sulphate and then solvent from it distilled off completely to get the title compound. Yield: 24 grams
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; ESWARAIAH, Sajja; SATYANARAYANA, Revu; KONDAL REDDY, Bairy; SRINIVAS, Aluru; WO2010/122578; (2010); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem