Electric Literature of 6705-33-5,Some common heterocyclic compound, 6705-33-5, name is Pyrazin-2-ylmethanol, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Powdered potassium hydroxide (3.4 g, 60 mmol) was added to a mixture of 2-chloro- L-FLUORO-4-NITROBENZENE (10.5 g, 60 mmol) AND PYRAZIN-2-YLMETHANOL (6.6 g, 60 mmol ; Maury G. et al. , Bull. Soc. Chem. Belg. 1982,91, 153). Tetrabutylammonium bromide (50 mg) was added and the mixture was heated AT 80C for one hour and cooled to room temperature. The residue was dissolved in dichloromethane, washed with water and dried over magnesium sulfate. After evaporation of the solvents, the residue was purified by chromatography on silica gel (eluant: 5% ethyl acetate in dichloromethane) to give 2- [ (2-CHLORO-4- nitrophenyl) oxymethyl] pyrazine (6.4 g, 40%) as a yellow solid. NMR Spectrum: (CDC13) 5.41 (s, 2H), 7.14 (d, 1H), 8.18 (dd, 1H), 8. 35 (d, 1H), 8.61 (d, 2H), 8.94 (s, 1H).
The synthetic route of 6705-33-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/26151; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem