At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Aminopyrazine-2-carbonitrile, and friends who are interested can also refer to it.
Adding a certain compound to certain chemical reactions, such as: 113305-94-5, name is 5-Aminopyrazine-2-carbonitrile, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 113305-94-5, category: Pyrazines
2- (2-Amino-4-methyl- phenoxymethyl) -morpholine-4-carboxylic acid tert-butyl ester (0.087 g, 0.270 mmol) was prepared from 2-amino-4- methyl-phenol according to methods of Compound 3, Steps 1 EPO and 2 using 2-hydroxymethyl-morpholine-4-carboxylic acid tert-butyl ester (prepared according to the procedure for Compound 2, Step 1 using the corresponding acid) and 4- methyl-2-nitro-phenol. It was combined with tr+/-phosgene (0.029 g, 0.10 mmol) , toluene (2 mL) and Hunig’s base(0.15 mL, 0.86 mmol), and stirred at room temperature for 25 min. The suspension then was transferred through a cannula to a cold solution (-780C) containing 5-amino- pyrazine-2-carbonitrile (0.032 g, 0.27 mmol), and lithium bis (trimethylsilyl) amide (0.27 mmol) in THF (1 mL) , which had been stirring at -78C for 30 min. The reaction was allowed to warm, then was stirred for 16 h at room temperature. A precipitate formed and was collected by- filtration to yield the desired product (0.043 cj).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Aminopyrazine-2-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; ICOS CORPORATION; WO2006/105262; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem