1458-01-1, name is Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C6H7ClN4O2
To a suspension of 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid methyl ester (10.0 g, 49.35 mmol) in methanol (5 mL) was added lithium hydroxide solution (4.17 g, 98.7 mmol in 40 mL water) at room temperature. The reaction was heated to 50 °C and stirred for 2-3 h. The temperature was lowered to room temperature and the reaction stirred overnight. The resulting precipitate was collected by filtration and dried under vacuum to yield 5 (11.3 g, 97percent). Mass (m/z): 187 [M-Li].
The synthetic route of 1458-01-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH; SCHULTZ, Peter G.; CHATTERJEE, Arnab K.; KUMAR, Manoj; WELZEL, Gustav; WO2015/3083; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem