Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1196152-38-1, name is 2-Bromo-5-(trifluoromethyl)pyrazine, A new synthetic method of this compound is introduced below., name: 2-Bromo-5-(trifluoromethyl)pyrazine
Step 25 A: 2-[(3R.5R)-3.5-dimethylpiperazin-l -yll-5-(trifluoromethyl)pyrazine (0923) To a solid mixture of (2R,6R)-2,6-dimethylpiperazine dihydrochloride (0924) (0.08 g, 0.44 mmol, 1.0 eq), sodium fert-butoxide (0.21 g, 2.2 mmol, 5.0 eq) and bis(tri- ter/-butylphosphine)palladium(0) (34 mg, 0.07 mmol, 0.15 eq) was added dioxane (4 mL) followed by 2-bromo-5-(trifluoromethyl)pyrazine (0.10 g, 0.44 mmol, 1.0 eq) and the reaction mixture stirred at 50C overnight. The resulting suspension was filtered thru a pad of celite using EtOAc and concentrated. Silica gel column (24 g) was loaded using methylene chloride and run using an increasing gradient of MeOH (0-20%) in methylene chloride over 25 min. Following concentration of the product eluents, 2- [(3R,5R)-3,5-dimethylpiperazin-l-yl]-5-(trifluoromethyl)pyrazine 25a (0.09 g, 0.33 mmol, 75%) was isolated as a yellow oil.
The synthetic route of 1196152-38-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NEUROCRINE BIOSCIENCES, INC.; HARRIOTT, Nicole; PAGANO, Nicholas; (135 pag.)WO2017/79641; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem