Reference of 41110-33-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41110-33-2, name is Methyl 5-methylpyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
To the starting material methyl 5-methylpyrazine-2-carboxylate (500 mg 3.3 mmol), THF was added and this was cooled to -78 C, followed by the addition of a 1.0 M methylenechloride solution of DIBAL-H (590 mg 3.6 mmol) and the mixture was stirred for 6 h at-78 C. TLC revealed very little starting material (>5%). The reaction mixture wasremoved from the dry ice bath and was quenched as per Fieser workup. Then 0.14 mLof water was slowly added followed by the addition of ethyl acetate 15 mL, add 0.14 mL15% aqueous sodium hydroxide. Then 0.36 mL water was added, warmed to rt and stirredfor 15 min after addition of Na2SO4 (250 mg). The reaction mixture was filtered over Hyflobed and the bed was washed thoroughly with EtOAc (50 mL). The organic layer wasevaporated under reduced pressure to dryness and purified using silica-gel flashchromatography. The pure product was characterized by NMR. Yield: 78%
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 5-methylpyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Balasubramaniam, Sivaraman; Vijayan, Sajith; Goldman, Liam V.; May, Xavier A.; Dodson, Kyra; Adhikari, Sweta; Rivas, Fatima; Watkins, Davita L.; Stoddard, Shana V.; Beilstein Journal of Organic Chemistry; vol. 16; (2020); p. 628 – 637;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem