Application of 74290-69-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74290-69-0 name is 5-Bromo-6-methylpyrazin-2-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 6: methyl 5-amino-3-methylpyrazine-2-carboxylate A 5 L pressure tank reactor was charged with 5-bromo-6-methylpyrazin-2-amine (510 g, 2.71 mol, 1.00 equiv), triethylamine (830 g, 8.22 mol, 3.02 equiv), methanol (3.5 L) and Pd(dppf)Cl2 (60 g). The reactor was pressurized with CO gas (10 atm) and was stirred for 24 h at 70 C. The pressure was then released; and the resulting solid was filtered off. The filtrate was concentrated under vacuum. Water was added to the resulting residue and the mixture was extracted with ethyl acetate (6 x 1 L). The combined organic layers were dried over anhydrous sodium sulfate and concentrated under vacuum to give the title compound, which was used in the next step without further purification.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromo-6-methylpyrazin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; COLLETTI, Steven, L.; DEMONG, Duane; DYKSTRA, Kevin, D.; HU, Zhiyong; MILLER, Michael; (104 pag.)WO2019/99315; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem