Application of 19838-07-4, The chemical industry reduces the impact on the environment during synthesis 19838-07-4, name is 3-Methylpyrazin-2(1H)-one, I believe this compound will play a more active role in future production and life.
[00596] Step A: To a solution of Ph3P (0.1573 g, 0.5999 mmol) and DIAD (0.1182 mL, 0.5999 mmol) in THF (5.713 mL) was added tert-butyl (3-bromo-1-((1r,4r)-4-hydroxycyclohexyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)(methyl)carbamate (0.243 g, 0.5713 mmol) and 2-hydroxy-3-methylpyrazine (0.09437 g, 0.8570 mmol) and stirred overnight. One equivalent each of DIAD, Ph3P and 2-hydroxy-3-methylpyrazine were mixed in 0.5 mL THF and the THF mixture was added to the reaction, which was then stirred for1 h. The reaction mixture was partitioned between ethyl acetate (25 mL) and water (25 mL), extracted with ethyl acetate (2x10mL), washed with water (2×10 mL) and brine (10 mL), dried over Na2SO4, filtered and concentrated. The residue was purified over silica gel (5-60% EtOAc in hexanes) to afford tert-butyl (3-bromo-1-((1s,4s)-4-((3-methylpyrazin-2-yl)oxy)cyclohexyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)(methyl)carbamate (0.319 g, 0.6165 mmol, 107.9 % yield).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methylpyrazin-2(1H)-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ARRAY BIOPHARMA INC.; ALLEN, Shelley; BOYS, Mark Laurence; COOK, Adam; GAUDINO, John; HINKLIN, Ronald Jay; LAIRD, Ellen; MCNULTY, Oren T.; METCALF, Andrew T.; NEWHOUSE, Brad; ROBINSON, John E.; (545 pag.)WO2019/113190; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem