Synthetic Route of 95-89-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 95-89-6, name is 3-Chloro-2,5-dimethylpyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
EXAMPLE 26; 2,5-Dimethyl-3-(5-methyl-3-phenyl-isoxazol-4-ylethynyl)-pyrazine; As described for example 11c, 4-ethynyl-5-methyl-3-phenyl-isoxazole (66 mg, 0.36 mmol) was converted [using 3-iodo-2,5-dimethyl-pyrazine (prepared from 3-chloro-2,5-dimethyl-pyrazine according to J. Med. Chem. (19) 490, 1976) instead of 2-chloro-4-iodopyridine] to the title compound (SiO2, heptane:ethyl acetate=95:5 to 0:100, 89 mg, 85%) which was obtained as a white solid. MS: m/e=290.1 [M+H]+.
The synthetic route of 3-Chloro-2,5-dimethylpyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Buettelmann, Bernd; Knust, Henner; Thomas, Andrew; US2007/287739; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem