Related Products of 762240-92-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
N,N-dimethylformamide (96.0 L) to (3R)-3-[N-(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid (12.00 kg) and 3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-alpha]pyrazine hydrochloride (9.05 kg) was added, stirring and the temperature was cooled to -5 C to 0 C. N-methylmorpholine (4.01 kg) and 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (8.28 kg) were added, After stirring for 1 hour at -5 C to 0 C and warmed to 20 C to 25 C and stirred for 3 hours. Ethyl acetate (192.0 L) and purified water (96.0 L) were added to the reaction mixture, which was then stirred for 10 minutes. The organic layer was separated, and the separated water layer was extracted with ethyl acetate (48.0 L) once more for 10 minutes to collect the organic layers. The combined organic layer was washed successively with 5% aqueous sodium carbonate solution and washed with a (sodium carbonate: 96.0 L: 4.8 kg, purified water). Dehydrated with anhydrous magnesium sulfate (12.0 kg) for 10 minutes, filtered and washed with ethyl acetate (24.0 L) and concentrated under reduced pressure. cyclohexane (240.0 L) was put into the obtained residue, and it stirred at 70 degreeC-72 degreeC for 5 minutes. After cooling to 20 to 25 stirred for 1 hour, filtered and washed with cyclohexane (36.0 L). Vacuum drying at 40 C to 45 C. the desired compound 7-[(3R)-3-[(N-tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-alpha]pyrazine (15.70 kg, yield : 85.9%) was obtained.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Most Medicine Co., Ltd.; Hong Seung-min; Shin So-yeong; Kang Seok-won; (10 pag.)KR2019/60235; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem