Related Products of 5521-55-1,Some common heterocyclic compound, 5521-55-1, name is 5-Methylpyrazine-2-carboxylic acid, molecular formula is C6H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 41 2 (R)- (3-CHLORO-4-METHANESULFONYL-PHENYL)-3-CYCLOPENTYL-N- (5- [1, 3] dioxolan-2-yl- pyrazin-2-yl)-propionamide [000241] A solution of 5-methylpyrazine-2-carboxylic acid (5.0 g, 36.2 mmol), N, N-dimethylformamide dimethyl acetal (15 mL, 113 mmol) ANDN, N-DIMETHYFORMAMIDE (15 mL) was heated with stirring in an oil-bath at 90C under argon for 60 min. The temperature of the oil-bath was raised to 120C, and the heating and stirring continued for an additional 120 min. The reaction mixture was then cooled to 25C and concentrated in vacuo to a volume of about 10 mL. The oily residue was partitioned with water (50 mL) and ethyl acetate (50 mL). The aqueous phase was further extracted with ethyl acetate (2 x 50 mL), and each organic extract was washed with a portion of a saturated aqueous sodium chloride solution (25 mL). The combined organic extracts were dried over sodium sulfate, filtered, and concentrated in vacuo to a dark oil. The residue was treated with a solution of diethyl ether/hexanes (50 mL, 3: 2) to produce an orange solid. The solid was collected by filtration and washed with a mixture of diethyl ether/hexanes (25 mL, 1: 1) to afford 5- (2-DIMETHYLAMINO-VINYL)-PYRAZINE-2-CARBOXYLIC acid methyl ester (4.94 g, 66 %) as a bright orange solid.
The synthetic route of 5521-55-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2004/52869; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem