In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33332-25-1, name is Methyl 5-chloropyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. name: Methyl 5-chloropyrazine-2-carboxylate
a) Methyl 5 -(3,3 -difluoroazetidin- 1 -yl)pyrazine-2-carboxylateTo a stirred solution of methyl 5-chloropyrazine-2-carboxylate (2.0 g, CAS 33332-25-1) in dioxane (45 ml) were added 3,3-difluoroazetidine hydrochloride (1.9 g, CAS 288315-03-7) andtriethylamine (4.19 ml). The reaction mixture was stirred at 45 C overnight. TLC analysis showed the reaction was complete. The reaction mixture was poured into aq. brine and extracted twice with ethyl acetate. The combined organic phases were dried over Na2SO4 and concencentrated in vacuo. The residue was purified by flash column chromatography (silica gel; eluent: 50% ethyl acetate in heptane) to afford methyl 5-(3,3-difluoroazetidin-1-yl)pyrazine-2-carboxylate (1.21 g, 46%) as a white solid. MS (ISP): 230.2 ([M+H]j.
The synthetic route of 33332-25-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GALLEY, Guido; NORCROSS, Roger; PFLIEGER, Philippe; WO2014/72257; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem