Application of 33332-28-4, These common heterocyclic compound, 33332-28-4, name is 2-Amino-6-chloropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Acetic acid (600mg, 10 mmol) was added to a solution of 3-(cyclopentyloxy)-4- methoxybenzaldehyde (440mg, 2 mmol) , 6-chloropyrazin-2-amine (258 mg, 2 mmol) and sodium triacetoxyborohydride (1.2 g, 5.6 mmol) in 30 mL dichloroethane at room temperature. The resulting mixture was warmed up to 600C and stirred for 4 hours. The reaction mixture was quenched with water. The product was extracted with DCM (3x20ml). The organic layer was separated and dried over sodium sulfate. The organic solvent was evaporated to dryness. The crude product was purified by SiO2 column chromatography to give lOOmg of 6-chloro-N-(3-(cyclopentyloxy)-4-methoxybenzyl)pyrazin-2-amine. Yield: 15percent
Statistics shows that 2-Amino-6-chloropyrazine is playing an increasingly important role. we look forward to future research findings about 33332-28-4.
Reference:
Patent; LEXICON PHARMACEUTICALS, INC.; BOMONT, Catherine; DEVASAGAYARAJ, Arokiasamy; JIN, Haihong; MARINELLI, Brett; SAMALA, Lakshama; SHI, Zhi-Cai; TUNOORI, Ashok; WANG, Ying; WO2010/39957; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem