Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 914452-71-4, name is 2-Bromo-6-methylpyrazine, A new synthetic method of this compound is introduced below., Computed Properties of C5H5BrN2
To a solution of 2-bromo-6-methyl-pyrazine (300 mg, 1.7 mmol), hexamethylditin (0.45 mL, 2.1 mmol), and tetrakis(triphenylphosphine) (142 mg, 0.123 mmol) in 1,4-dioxane 8.0 mL was purged with N2 for 5 min. The reaction mixture was stirred at 100 C for 1 8h. The reaction was filtered through celite. The crude product was used in next step. MS (ESI) m/z: 259.1.
The synthetic route of 914452-71-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; DO, Steven; HU, Huiyong; KOLESNIKOV, Aleksandr; TSUI, Vickie, H.; WANG, Xiaojing; WO2014/1377; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem