Synthetic Route of 22047-25-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 22047-25-2 name is Acetylpyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A 0.5 M solution of ethynylmagnesium chloride in tetrahydrofuran (31.90 mmol, Aldrich) is diluted with 50 ml of tetrahydrofuran and then cooled to 0 C. 3 g of 1-pyrazin-2-ylethanone (24.56 mmol, Lancaster) are then added in several fractions, and the mixture is stirred at 0 C. for 4 hours. The mixture is cooled once again with an ice bath and a solution of NH4Claq is added slowly. The mixture is extracted twice with ethyl acetate and the organic phases are then combined, dried over sodium sulphate, filtered, and concentrated under vacuum. The oily residue obtained is purified by silica chromatography (elution with a cyclohexane:ethyl acetate gradient, 70:30 to 50:50) and 2.9 g of the expected product are obtained in the form of a yellow oil (yield=80%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Acetylpyrazine, and friends who are interested can also refer to it.
Reference:
Patent; SANOFI-AVENTIS; US2010/144757; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem