Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 56423-63-3, name is 2-Bromopyrazine, A new synthetic method of this compound is introduced below., Recommanded Product: 56423-63-3
A mixture of 4-bromo-2,6- difluorobenzaldehyde (2 g, 9.05 mmol), bis (pinacolato) diboron (3.22 g, 12.67 mmol), dichloro1,1?-bis(diphenylphosphino)ferrocene palladium (II) dichloromethane (739.04 mg, 0.9 mmol)and potassium acetate (1776.34 mg, 18.1 mmol) in 1, 4-dioxane (18 mL) were heated to 90Cfor 12 hours. After cooling to room temperature 2-bromopyrazine (1.64 ml, 18.1 mmol),tetrakis(triphenylphosphine)palladium (1. 05g, 0.9 mmol) and potassium carbonate (2 M, 11.31ml) were added. The mixture was degassed by pulling vacuum and back-filling with Ar (3x),then the reaction was heated to 90C for 12 horns, cooled to room temperature, diluted with EtOAc and washed with saturated solution of brine. The organic extract was dried over Na2SO4, filtered and concentrated under reduced pressure. The cmde residue was purified by silica column chromatography (0% – 100% EtOAc /DCM/) to afford P36 MS (ESI) mlz 221.1[M+Hjt
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GILEAD SCIENCES, INC.; BACON, Elizabeth M.; CHIN, Elbert; COTTELL, Jeromy J.; KATANA, Ashley Anne; KATO, Darryl; LINK, John O.; SHAPIRO, Nathan; TREJO MARTIN, Teresa Alejandra; YANG, Zheng-Yu; (395 pag.)WO2018/145021; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem