Synthetic Route of 41270-66-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41270-66-0 name is 5-Chloro-2,3-diphenylpyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[123] Step 1. 2-(1.1.2.2.3.3.4.4-dg-4-((5.6-Diphenylpyrazin-2-yl)(propan-2-yl)amino)butan- l-ol (12b). To a solution of commercially available 5-chloro-2,3-diphenylpyrazine (10) (0.57 g, 2.14 mmol) in NMP (2.0 mL), was added d7-aminoalcohol lib (0.75 g, 5.35 mmol, 2.5 equiv, prepared as described in Example 10). The reaction vessel was sealed and heated to 190 0C for 15 hours, then cooled to ambient temperature. The mixture was diluted with ice water and extracted with Et2O (3 x 20 mL). The combined organic layers were washed successively with water and brine. The resulting organic layer was dried (MgSO4), filtered and concentrated in vacuo. The resulting residue was purified by column chromatography (SiO2, 30-50% EtO Ac/heptane) to afford 12b (0.20 g, 25%). MS (M+H): 370.0
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Chloro-2,3-diphenylpyrazine, and friends who are interested can also refer to it.
Reference:
Patent; CONCERT PHARMACEUTICALS, INC.; HARBESON, Scott L.; MASSE, Craig E.; LIU, Julie F.; WO2011/17612; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem