These common heterocyclic compound, 19847-12-2, name is Pyrazinecarbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C5H3N3
Alternatively, 2-pyrazinecarboxamidine hydrochloride can be prepared as follows: A solution of 2-pyrazinecarbonitrile (21 g, 200 mmol) in a mixture of 10 mL of methyl alcohol and 120 mL of diethyl ether is treated with hydrogen chloride gas at 0 C. The mixture is then stored at 5 C. for 3 days. The precipitates are collected by filtration and and dried. This solid is then suspended in 100 mL of ethyl alcohol and the mixture is treated with ammonium gas at 0 C. The mixture is then stored at 5 C. for 4 days, and filtered. Concentration of the filtrate gives 2-pyrazinecarboxamidine hydrochloride as a tan solid (2.8 g).
The synthetic route of Pyrazinecarbonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Wyeth; US2005/75357; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem