Application of 1379338-74-5, A common heterocyclic compound, 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, molecular formula is C7H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate 32: 1,1-Dimethylethyl {4-[(7-chloropyrido[3,4-b]pyrazin-5-yl)amino]butyl}carbamate To 5,7-dichloropyrido[3,4-b]pyrazine (650 mg, 3.25 mmol) was added 1,1-dimethylethyl (4-aminobutyl)carbamate (0.622 ml, 3.25 mmol) (Fluka) and diisopropylethylamine (0.851 ml, 4.87 mmol). To the mixture was added N-methyl-2-pyrrolidone (NMP) (10 ml). The microwave vial was sealed and heated to 130 C. for 30 min. The reaction mixture was partitioned between water (70 ml) and ethyl acetate (70 ml) and then separated. The aqueous layer was extracted with ethyl acetate (2*50 ml). The combined organics were passed through a phase separation cartridge and reduced in vacuo. The residue was dissolved in DCM and loaded onto a silica cartridge (50 g) and purified via SP4 using a 15-75% EtOAc in cyclohexane gradient. The appropriate fractions were combined and concentrated to give the title compound as a yellow film (1.01 g). LCMS (Method C): Rt=1.11 min, MH+=352.0
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GLAXO GROUP LIMITED; Atkinson, Francis Louis; Atkinson, Stephen John; Barker, Michael David; Douault, Clement; Garton, Neil Stuart; Liddle, John; Patel, Vipulkumar Kantibhai; Preston, Alexander G.; Shipley, Tracy Jane; Wilson, David Matthew; Watson, Robert J.; US2014/5188; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem