Electric Literature of 912773-24-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 912773-24-1 as follows.
General procedure: In a 1000ml three-necked flask, equipped with mechanical stirring, Ar gas protection, adding 3-phenyl-6-chloroimidazo [1,2-a] pyrimidine (7.16 g (molecular weight: 229, 0.030 mol), p-bromophenyl boronic acid pinacol ester 9.1 g (molecular weight: 282, 0.032 mol), catalyst Pd (PPh3) 4 was used in an amount of 1.8 g (molecular weight 1154, 0.001556 mol), 120 ml of a sodium carbonate aqueous solution (2M), 300 ml of toluene and 150 ml of ethanol. Stirring reflux, with TLC monitoring reaction, reaction 3.5hs after the reaction is complete. Cooled, separated, evaporated to dryness, using column chromatography The eluent was eluted with 1: 3 ethyl acetate: petroleum ether to give 9.0 g of a pale yellow solid having a purity of 97.0% and a yield of 83.2%. The synthesis step was the same as the fourth step in Example 1,Except that 3-phenyl-6-chloroimidazo[1,2, a]pyrimidine was added Substituted with 6-bromoimidazo [1,2-A]pyrazine,(3-phenylcarbazole-9-yl) -6,6,12,12-tetramethyl-6,12-dihydroindeno [1,2-b ] Fluorene-2-boronic acid pinacol ester instead of raw materials, other raw materials and process unchanged, Compound 29 was obtained.
According to the analysis of related databases, 912773-24-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Gu’an Dingcai Technology Co., Ltd.; Li Yinkui; Tang Jinming; Fan Hongtao; (40 pag.)CN104650089; (2017); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem