Some common heterocyclic compound, 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile, molecular formula is C5HCl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 3,5-Dichloropyrazine-2-carbonitrile
11010] To a solution of 3,5-dichloropyrazine-2-carbonitrile(500 mg, 2.87 mmol) in DMF (10 mE) was added (R)-(3-130C-amino)piperidine (690 mg, 3.45 mmol) and then DIEA(1.0 mE, 5.74 mmol) in a dropwise manner. The mixture wasstirred at RT for 90 mm. The mixture was diluted with EtOAc(200 mE), washed with water x2, dried, and concentrated invacuo. The residue was subjected to flash column chromatog-continued raphy with 0 to 25% EtOAc in DCM to isolate (R)-tert-butyl 1 -(6-chloro-5-cyanopyrazin-2-yl)piperidin-3-ylcarbamate (87) (940 mg, 97% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 313339-92-3, its application will become more common.
Reference:
Patent; JIA, Zhaozhong J.; CHEN, Wei; THOMAS, William D.; US2015/158865; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem