These common heterocyclic compound, 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 5,7-Dichloropyrido[3,4-b]pyrazine
To a solution of 4-hydroxycyclohexanone (171 mg, 1.5 mmol) in dloxane was added Cs2CO3 (488 mg, 1.5 mmol) and 5,7-dichloropyrido[4,3-b]pyrazine (200 mg, 1.0mmo) at room temperature. The mixture was stirred at 80 C for 18 hours. After that,the 5,7-dichloropyrido[4,3-b]pyrazine was consumed and the reaction was used for next step directly.
The synthetic route of 5,7-Dichloropyrido[3,4-b]pyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DENG, Wei; WO2014/86032; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem